We had a great Network day with guest speakers Frank Kjeldsen from the Department of Biochemistry and Molecular Biology, SDU Odense and Yvonne Kohl from the Fraunhofer Institute for Biomedical Engineering in Sulzbach, Germany.
Basis for the meeting is the fact that a serious lack of information concerning the potential health risks of nano-sized materials leads to the need for new sensitive models and technologies to assess the risks of nanomaterial-cell interactions. Frank Kjeldsen, SDU, gave us insights into the groups experiments with detection of silver nanoparticles in vitro and their observations on toxicity. He states that there are more than 3000 products on the market with nano inside (www.nanodb.dk/en) and that silver has a high share in these products. Applying mass spectrometry and proteomics they studied the effects of nanoparticles on proteins. An important result of these studies revealed that the exposure of cells to Cadmium and Silver nanoparticles causes more radicals than the sum of both. Additionally it is known that silver accumulates for a long time in the body and the shape of the particles also matters in the uptake rate. So we need to be careful blending different kinds of nanoparticles in consumer products and do more investigations of this kind.
At IBMT they study nanoparticles in the whole lifecycle from production to use and recycling. Yvonne Kohl introduced us to their experiments with a transparent membrane with pores to simulate what happens in an organ. The method is in-vivo like and does not involve animal testing. In different scenarios starting with polystyrol particles they compare nano and micro size effects and also compare charging effects. They do SEM or TEM imaging on the chips where they grow the cells. Furthermore, she presented results of the H2020 project HISENTS “High level Integrated Sensor for Nanotoxicity Screening“ (GA no. 685817).
The day ended with discussions and a lab tour for all participants.
During the day we recorded interviews and you can meet Frank Kjeldsen in the recorded film, that is available with Danish and German subtitles on our HOME page.